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Translational Pharmacology is the translation of knowledge gained to advance the innovation into practice in a clinical setting, in the form of听medications to treat conditions of the brain.听

Our team contributes to the discovery and development of new therapeutics for disorders that currently lack safe and effective treatments or where the existing therapeutics have substantial room for improvement. Our research questions are focused on improving our ability to:

• Translate findings in human patient populations.听
• Translate findings in cellular models into complex disease models.听
• Translate results in complex disease models into the clinic.

Our early priority program includes a focus on novel preclinical and early clinical stage therapeutics developed for treating social dysfunction and neurodevelopmental disorders and for managing various symptoms in dementia.

Other major programs include: understanding the mechanisms driving the transition from acute to chronic pain to facilitate the development of more effective treatments.

Our work also goes towards supporting the development of KNX100, one of the only novel molecular entities in clinical development, for the treatment of opioid use disorder globally.听

To conduct this work, we will partner across academia, industry and government and utilise a range of techniques including genetic tools, omics, disease models, real-time in-vivo recordings, advanced computing, microscopy, and preclinical and clinical imaging.听

Journals

• Tan O, Bowen MT.听(2023). The vasopressin V1A receptor and aggression: Challenges and potential novel treatments. In,听Anger, Aggression and Violence: Causes, Pathology and Treatments.听Springer-Nature.听
• Raymond JS, Everett NA, Gururajan A, Bowen MT. (2023). The influence of intraperitoneal and intranasal oxytocin on sleep-wake behaviour and neurophysiology in rats.听Sleep.听
• Scicluna RL, Wilson BB, Thelaus SH, Arnold JC, McGregor IS, Bowen MT.听(2022). Cannabidiol reduced the severity of gastrointestinal symptoms of opioid withdrawal in male and female mice.听Cannabis and Cannabinoid Research.听
• Milligan, C., Anderson, L., Bowen, M., Banister, S., McGregor, I., Arnold, J., Petrou, S. (2022). A nutraceutical product, extracted from Cannabis sativa, modulates voltage-gated sodium channel function.听Journal of Cannabis Research, 4(1).听[More Information]
  
• Bowen, M., George, O., Muskiewicz, D., Hall, F. (2022). FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION.听Neuroscience and Biobehavioral Reviews, 132, 730-756.听[More Information]
  
• Kevin, R., Cairns, E., Boyd, R., Arnold, J., Bowen, M., McGregor, I., Banister, S. (2022). Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11.听Frontiers in Psychiatry, 13.听[More Information]
  
• Rehn, S., Raymond, J., Boakes, R., Bowen, M. (2022). Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day.听Psychopharmacology, 239(2), 429-442.听[More Information]
• Mungoven, T., Marciszewski, K., Macefield, V., Macey, P., Henderson, L., Meylakh, N. (2022). Alterations in pain processing circuitries in episodic migraine.听Journal of Headache and Pain, 23(1), 9.听
• Lee, B., Di Pietro, F., Henderson, L., Austin, P. (2022). Altered basal ganglia infraslow oscillation and resting functional connectivity in complex regional pain syndrome.听Journal of Neuroscience Research, 100(7), 1487-1505.听
• Pal, A., Martinez, F., Chatterjee, R., Aysola, R., Harper, R., Macefield, V., Henderson, L., Macey, P. (2022). Baroreflex sensitivity during rest and pressor challenges in obstructive sleep apnea patients with and without CPAP.听Sleep Medicine, 97, 73-81.听
• Meylakh, N., Henderson, L. (2022). Exploring alterations in sensory pathways in migraine.听Journal of Headache and Pain, 23(1), 5.听
• Robertson, R., Crawford, L., Meylakh, N., Macey, P., Macefield, V., Keay, K., Henderson, L. (2022). Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: A 7-Tesla functional magnetic resonance imaging study.听NeuroImage, 259.听
• Mandwie, M., Piper, J., Gorrie, C., Keay, K., Musumeci, G., Al-Badri, G., Castorina, A. (2022). Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury.听Neural Regeneration Research, 17(2), 378-385.听
• Robertson, R., Crawford, L., Meylakh, N., Macey, P., Macefield, V., Keay, K., Henderson, L. (2022). Regional hypothalamic, amygdala, and midbrain periaqueductal gray matter recruitment during acute pain in awake humans: A 7-Tesla functional magnetic resonance imaging study.听NeuroImage, 259.听
• Sosa, M., Boorman, D., Keay, K. (2022). Sciatic nerve injury rebalances the hypothalamic pituitary adrenal axis in rats with persistent changes to their social behaviours.听Journal of Neuroendocrinology, 34(6).听
• Boorman, D., Keay, K. (2022). Sex differences in morphine sensitivity are associated with differential glial expression in the brainstem of rats with neuropathic pain.听Journal of Neuroscience Research, 100(10), 1890-1907.听
• Wu, A., Xiao, Q., McWatt, S., Utomo, R., Talis, A., Saraci, K., Brassett, C., Sagoo, M., Wingate, R., Chien, C., Keay, K., et al (2022). The Anatomy Course During COVID-19: The Impact of Cadaver-Based Learning on the Initiation of Reflection on Death.听Medical Science Educator, 32(5), 1033-1044.听